BAIT
INS
IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10
insulin
GO Process (60)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IDA]
- activation of protein kinase B activity [IDA]
- acute-phase response [IDA]
- alpha-beta T cell activation [IDA]
- cell-cell signaling [IC]
- cellular protein metabolic process [TAS]
- endocrine pancreas development [TAS]
- energy reserve metabolic process [TAS]
- fatty acid homeostasis [IMP]
- glucose homeostasis [IMP]
- glucose transport [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of NAD(P)H oxidase activity [IDA]
- negative regulation of acute inflammatory response [IDA]
- negative regulation of fatty acid metabolic process [IMP]
- negative regulation of feeding behavior [IDA]
- negative regulation of gluconeogenesis [NAS]
- negative regulation of glycogen catabolic process [IMP]
- negative regulation of lipid catabolic process [IMP, NAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [NAS]
- negative regulation of protein catabolic process [IDA]
- negative regulation of protein oligomerization [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of proteolysis [IMP]
- negative regulation of respiratory burst involved in inflammatory response [IDA]
- negative regulation of vasodilation [NAS]
- positive regulation of DNA replication [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of brown fat cell differentiation [TAS]
- positive regulation of cell differentiation [NAS]
- positive regulation of cell growth [NAS]
- positive regulation of cell migration [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cytokine secretion [IDA]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IDA, IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of lipid biosynthetic process [NAS]
- positive regulation of mitosis [IDA]
- positive regulation of nitric oxide biosynthetic process [NAS]
- positive regulation of nitric-oxide synthase activity [NAS]
- positive regulation of peptide hormone secretion [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [ISS]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of respiratory burst [IDA]
- positive regulation of vasodilation [NAS]
- regulation of cellular amino acid metabolic process [IMP]
- regulation of insulin secretion [TAS]
- regulation of protein localization [IDA]
- regulation of protein secretion [IDA]
- regulation of transcription, DNA-templated [NAS]
- regulation of transmembrane transporter activity [IDA]
- small molecule metabolic process [TAS]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SRC
ASV, SRC1, c-SRC, p60-Src, RP5-823N20.1
SRC proto-oncogene, non-receptor tyrosine kinase
GO Process (50)
GO Function (17)
GO Component (10)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Ras protein signal transduction [TAS]
- T cell costimulation [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- bone resorption [IBA, ISS]
- cell adhesion [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to progesterone stimulus [ISS]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [IBA, TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [IBA, TAS]
- integrin-mediated signaling pathway [IMP]
- intracellular estrogen receptor signaling pathway [IBA]
- intracellular signal transduction [IDA]
- leukocyte migration [TAS]
- membrane organization [TAS]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of protein homooligomerization [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoclast development [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet activation [TAS]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of integrin activation [TAS]
- positive regulation of protein kinase B signaling [IMP]
- progesterone receptor signaling pathway [IBA, ISS]
- protein autophosphorylation [IDA]
- regulation of bone resorption [TAS]
- regulation of caveolin-mediated endocytosis [IMP]
- regulation of cell cycle [IBA]
- regulation of cell proliferation [IBA]
- regulation of cell-cell adhesion [IMP]
- regulation of early endosome to late endosome transport [IMP]
- regulation of epithelial cell migration [IMP]
- regulation of podosome assembly [IBA]
- regulation of vascular permeability [TAS]
- response to interleukin-1 [IMP]
- signal complex assembly [TAS]
- signal transduction [TAS]
- stress fiber assembly [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- SH3/SH2 adaptor activity [TAS]
- enzyme binding [IPI]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IPI]
- heme binding [IDA]
- hormone receptor binding [IBA]
- integrin binding [TAS]
- ion channel binding [IPI]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, TAS]
- protein tyrosine kinase activity [EXP, IDA, TAS]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- SH2 domain binding [IPI]
- SH3/SH2 adaptor activity [TAS]
- enzyme binding [IPI]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IPI]
- heme binding [IDA]
- hormone receptor binding [IBA]
- integrin binding [TAS]
- ion channel binding [IPI]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, TAS]
- protein tyrosine kinase activity [EXP, IDA, TAS]
- receptor binding [IPI]
- scaffold protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.
The ?-cell protein synthetic machinery is dedicated to the production of mature insulin, which requires the proper folding and trafficking of its precursor, proinsulin. The complete network of proteins that mediate proinsulin folding and advancement through the secretory pathway, however, remains poorly defined. Here we used affinity purification and mass spectrometry to identify, for the first time, the proinsulin biosynthetic ... [more]
Diabetes Aug. 01, 2020; 69(8);1723-1734 [Pubmed: 32457219]
Throughput
- High Throughput
Curated By
- BioGRID