MTF2
Gene Ontology Biological Process
- negative regulation of histone H3-K27 methylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K27 methylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- segment specification [IMP]
- stem cell differentiation [IMP]
- stem cell maintenance [IMP]
Gene Ontology Molecular Function
SUZ12
Gene Ontology Biological Process
- histone H3-K27 trimethylation [ISO]
- histone methylation [IMP]
- histone ubiquitination [IMP]
- negative regulation of cell differentiation [ISO]
- negative regulation of chemokine production [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- positive regulation of cell proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ESC/E(Z) complex [IDA, ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- sex chromatin [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.
Trimethylation on histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) regulates the balance between self-renewal and differentiation of embryonic stem cells (ESCs). The mechanisms controlling the activity and recruitment of PRC2 are largely unknown. Here we demonstrate that the founding member of the Jumonji family, JMJ (JUMONJI or JARID2), is associated with PRC2, colocalizes with PRC2 and ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUZ12 MTF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 669467 | |
| SUZ12 MTF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 669478 | |
| MTF2 SUZ12 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 669479 | |
| SUZ12 MTF2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID