EGLN2
Gene Ontology Biological Process
- cell redox homeostasis [IDA]
- cellular response to hypoxia [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- positive regulation of protein catabolic process [IDA]
- regulation of cell growth [NAS]
- regulation of neuron apoptotic process [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [IDA]
EGLN3
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IEP]
- apoptotic process [IEP]
- cellular response to hypoxia [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein hydroxylation [IDA]
- regulation of cell proliferation [IEP]
- regulation of neuron apoptotic process [ISS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IEP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2.
PHD1-3 (prolyl hydroxylases 1-3) catalyse the hydroxylation of HIF (hypoxia-inducible factor)-alpha subunit that triggers the substrate ubiquitination and subsequent degradation. The RING (really interesting new gene) finger E3 ligase Siah2 preferentially targets PHD3 for degradation. Here, we identify the requirements for such selective targeting. Firstly, PHD3 lacks an N-terminal extension found in PHD1 and PHD2; deletion of this domain from ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EGLN3 EGLN2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID