Homo sapiens
EGLN2
EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1
egl-9 family hypoxia-inducible factor 2
GO Process (9)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- cell redox homeostasis [IDA]
- cellular response to hypoxia [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- positive regulation of protein catabolic process [IDA]
- regulation of cell growth [NAS]
- regulation of neuron apoptotic process [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [IDA]
Download Curated Data for this Protein
125184
9606
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- Interactors 40
- Interactions 52
- Chemical Interactions 2
- Network
- PTM Sites 2