MTOR
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- TOR signaling [IMP]
- cell growth [IDA, TAS]
- cellular response to hypoxia [ISS]
- cellular response to nutrient levels [ISS]
- double-strand break repair via homologous recombination [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth [NAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of autophagy [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phosphorylation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase III promoter [IMP]
- positive regulation of translation [IDA]
- protein autophosphorylation [IDA]
- protein catabolic process [TAS]
- protein phosphorylation [IDA, IMP]
- regulation of actin cytoskeleton organization [IMP]
- response to amino acid [IDA]
- response to nutrient [NAS]
- response to stress [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
PRR5
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth. Two complexes of mTOR have been identified: complex 1, consisting of mTOR-Raptor (regulatory associated protein of mTOR)-mLST8 (termed mTORC1), and complex 2, comprising mTOR-Rictor (rapamycininsensitive companion of mTOR)-mLST8-Sin1 (termed mTORC2). mTORC1 phosphorylates the p70 ribosomal S6K (S6 kinase) at its hydrophobic motif (Thr389), whereas mTORC2 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MTOR PRR5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 852278 | |
| PRR5 MTOR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID