TERF1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IEP]
- age-dependent telomere shortening [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of DNA replication [IDA]
- negative regulation of telomerase activity [IGI]
- negative regulation of telomere maintenance via semi-conservative replication [NAS]
- negative regulation of telomere maintenance via telomerase [IGI]
- positive regulation of apoptotic process [IDA]
- positive regulation of microtubule polymerization [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of mitotic cell cycle [IMP]
- protein homooligomerization [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS]
- telomeric loop formation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MTOR
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- TOR signaling [IMP]
- cell growth [IDA, TAS]
- cellular response to hypoxia [ISS]
- cellular response to nutrient levels [ISS]
- double-strand break repair via homologous recombination [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth [NAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of autophagy [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phosphorylation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase III promoter [IMP]
- positive regulation of translation [IDA]
- protein autophosphorylation [IDA]
- protein catabolic process [TAS]
- protein phosphorylation [IDA, IMP]
- regulation of actin cytoskeleton organization [IMP]
- response to amino acid [IDA]
- response to nutrient [NAS]
- response to stress [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tel2 regulates the stability of PI3K-related protein kinases.
We report an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, we found no obvious telomeric function for mammalian Tel2. Targeted gene deletion showed that mouse Tel2 is essential in embryonic development, embryonic stem (ES) cells, and embryonic ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID