BAIT
TRIM59
2310035M22Rik, 2700022F13Rik, Mrf1, TSBF1
tripartite motif-containing 59
GO Process (4)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CD74
CLIP, DHLAG, HLADG, Ia-GAMMA, Ii
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
GO Process (35)
GO Function (10)
GO Component (17)
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- antigen processing and presentation [IDA, IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- cell proliferation [ISO]
- chaperone mediated protein folding requiring cofactor [IDA, IMP]
- cytokine-mediated signaling pathway [IMP]
- defense response [IMP]
- immunoglobulin mediated immune response [IMP]
- intracellular protein transport [IDA, IMP]
- macrophage migration inhibitory factor signaling pathway [IDA]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP, ISO]
- negative regulation of T cell differentiation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP, ISO]
- negative regulation of mature B cell apoptotic process [IMP]
- negative regulation of peptide secretion [ISO]
- negative thymic T cell selection [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of T cell differentiation [IMP]
- positive regulation of adaptive immune response [NAS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- positive regulation of cytokine-mediated signaling pathway [IMP, ISO]
- positive regulation of dendritic cell antigen processing and presentation [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of innate immune response [IC]
- positive regulation of macrophage cytokine production [IDA]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of type 2 immune response [IMP]
- positive thymic T cell selection [IMP]
- prostaglandin biosynthetic process [ISO]
- protein complex assembly [IDA]
- protein folding [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- MHC class II protein binding [IPI]
- MHC class II protein binding, via antigen binding groove [ISO]
- MHC class II protein complex binding [ISO]
- beta-amyloid binding [ISO]
- cytokine binding [IDA, ISO]
- cytokine receptor activity [IMP, ISO]
- macrophage migration inhibitory factor binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
- MHC class II protein binding [IPI]
- MHC class II protein binding, via antigen binding groove [ISO]
- MHC class II protein complex binding [ISO]
- beta-amyloid binding [ISO]
- cytokine binding [IDA, ISO]
- cytokine receptor activity [IMP, ISO]
- macrophage migration inhibitory factor binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- MHC class II protein complex [IDA]
- NOS2-CD74 complex [IDA]
- cell surface [ISO]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [TAS]
- intracellular [IMP]
- late endosome [IDA]
- lysosome [IDA]
- macrophage migration inhibitory factor receptor complex [IDA, ISO]
- membrane [ISO]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP]
- vacuole [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.
TRIM family members have been implicated in a variety of biological processes such as differentiation and development. We here found that Trim59 plays a critical role in early embryo development from blastocyst stage to gastrula. There existed delayed development and empty yolk sacs from embryonic day (E) 8.5 in Trim59-/- embryos. No viable Trim59-/- embryos were observed beyond E9.5. Trim59 ... [more]
Cell Death Dis Feb. 21, 2018; 9(3);302 [Pubmed: 29467473]
Throughput
- Low Throughput
Curated By
- BioGRID