BAIT
ACVRL1
ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
activin A receptor type II-like 1
GO Process (37)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- activin receptor signaling pathway [IDA]
- angiogenesis [IMP]
- artery development [ISS]
- blood circulation [IMP]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [TAS]
- blood vessel maturation [TAS]
- blood vessel remodeling [ISS]
- cellular response to BMP stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- endothelial tube morphogenesis [IMP]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [IMP]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of blood vessel endothelial cell migration [IMP]
- negative regulation of cell adhesion [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of focal adhesion assembly [IMP]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of chondrocyte differentiation [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of DNA replication [TAS]
- regulation of blood pressure [IMP]
- regulation of blood vessel endothelial cell migration [TAS]
- regulation of endothelial cell proliferation [TAS]
- regulation of transcription, DNA-templated [IMP]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
- venous blood vessel development [ISS]
- wound healing, spreading of epidermal cells [IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A19
DNC, MCPHA, MUP1, THMD3, THMD4, TPC
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.409899351 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.409899350655887, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Curated By
- BioGRID