Publication

Identification and functional characterization of transcriptional activators in human cells.

Alerasool N, Leng H, Lin ZY, Gingras AC, Taipale M

Transcription is orchestrated by thousands of transcription factors (TFs) and chromatin-associated proteins, but how these are causally connected to transcriptional activation is poorly understood. Here, we conduct an unbiased proteome-scale screen to systematically uncover human proteins that activate transcription in a natural chromatin context. By combining interaction proteomics and chemical inhibitors, we delineate the preference of these transcriptional activators for ... [more]

Throughput

• High Throughput

Additional Notes

• Affinity-capture MS was carried out to identify high confidence protein-protein interactions with a Bayesian FDR cutoff of less than or equal to 5%

Curated By

• BioGRID