BAIT
FLO8
PHD5, STA10, YER108C, transcription factor FLO8, L000003202, S000000910, S000029523, L000004208, YER109C
Transcription factor; required for flocculation, diploid filamentous growth, and haploid invasive growth; forms a heterodimer with Mss1p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1; S. cerevisiae genome reference strain S288C contains an internal in-frame stop at codon 142, which in other strains encodes tryptophan
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- positive regulation of cell adhesion involved in single-species biofilm formation [IMP]
- positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
FUS3
DAC2, mitogen-activated serine/threonine-protein kinase FUS3, L000000655, YBL016W
Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- cell cycle arrest [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of MAPK cascade [IPI]
- negative regulation of transposition, RNA-mediated [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IDA]
- positive regulation of protein export from nucleus [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae.
Cellular responses to environmental stimuli require conserved signal transduction pathways. In budding yeast (Saccharomyces cerevisiae), nutrient limitation induces morphological changes that depend on the protein kinase A (PKA) pathway and the Kss1 mitogen-activated protein kinase (MAPK) pathway. It was unclear to what extent and at what level there is synergy between these two distinct signaling modalities. We took a systematic ... [more]
Genetics Jul. 01, 2010; 185(3);855-70 [Pubmed: 20421603]
Throughput
- Low Throughput
Ontology Terms
- invasive growth (APO:0000028)
Curated By
- BioGRID