BAIT

ZIP1

L000002568, YDR285W
Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

CDC5

MSD2, PKX2, polo kinase CDC5, L000000245, YMR001C
Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rholp guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

The Budding Yeast Polo-Like Kinase Cdc5 Regulates the Ndt80 Branch of the Meiotic Recombination Checkpoint Pathway.

Acosta I, Ontoso D, San-Segundo PA

Defects in chromosome synapsis and/or meiotic recombination activate a surveillance mechanism that blocks meiotic cell cycle progression to prevent anomalous chromosome segregation and formation of aberrant gametes. In the budding yeast zip1 mutant, lacking a synaptonemal complex component, the meiotic recombination checkpoint is triggered resulting in extremely delayed meiotic progression. We report that overproduction of the polo-like kinase Cdc5 partially ... [more]

Unknown Jul. 27, 2011; 0(0); [Pubmed: 21795394]

Throughput

  • Low Throughput

Ontology Terms

  • meiosis (APO:0000039)
  • sporulation efficiency (APO:0000044)

Additional Notes

  • overexpression of Cdc5 increases the sporulation efficiency and blocks the meiotic arrest in a zip1 mutant

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ZIP1 CDC5
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Low-BioGRID
3502721
ZIP1 CDC5
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
3502722
ZIP1 CDC5
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2450488

Curated By

  • BioGRID