ECE1
Gene Ontology Biological Process
- bradykinin catabolic process [IDA]
- calcitonin catabolic process [IDA]
- ear development [IMP]
- embryonic digit morphogenesis [IMP]
- endothelin maturation [IDA]
- heart development [IMP]
- hormone catabolic process [IDA]
- peptide hormone processing [IDA]
- positive regulation of receptor recycling [IMP]
- protein processing [IDA]
- regulation of systemic arterial blood pressure by endothelin [IC]
- regulation of vasoconstriction [IC]
- substance P catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Weibel-Palade body [IDA]
- early endosome [IDA]
- endosome [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IDA]
- intrinsic component of endosome membrane [TAS]
- lysosomal membrane [IDA]
- membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- vesicle [ISS]
KNG1
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- inflammatory response [TAS]
- negative regulation of blood coagulation [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of renal sodium excretion [TAS]
- positive regulation of urine volume [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.
Although cell surface metalloendopeptidases degrade neuropeptides in the extracellular fluid to terminate signaling, the function of peptidases in endosomes is unclear. We report that isoforms of endothelin-converting enzyme-1 (ECE-1a-d) are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors. Calcitonin gene-related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), beta-arrestin2, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID