BAIT
BCL2
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
B cell leukemia/lymphoma 2
GO Process (135)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- B cell homeostasis [IMP]
- B cell lineage commitment [IMP]
- B cell proliferation [ISO]
- B cell receptor signaling pathway [ISO]
- CD8-positive, alpha-beta T cell lineage commitment [IMP]
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IGI, IMP]
- T cell lineage commitment [IMP]
- actin filament organization [IMP]
- apoptotic mitochondrial changes [IDA]
- apoptotic process [IMP, ISO]
- axon regeneration [IDA]
- axonogenesis [IMP]
- behavioral fear response [IMP]
- branching involved in ureteric bud morphogenesis [IDA, IGI]
- cell aging [IMP]
- cell growth [IMP]
- cell morphogenesis [IMP]
- cell proliferation [IGI]
- cellular calcium ion homeostasis [IDA]
- cellular response to DNA damage stimulus [ISO]
- cellular response to glucose starvation [IDA]
- cellular response to hypoxia [IDA]
- cellular response to organic substance [IDA]
- cochlear nucleus development [IMP]
- defense response to virus [ISO]
- developmental growth [IMP]
- developmental pigmentation [IGI, IMP]
- digestive tract morphogenesis [IMP]
- ear development [IGI, IMP]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- focal adhesion assembly [IMP]
- gland morphogenesis [IMP]
- glomerulus development [IMP]
- growth [IMP]
- hair follicle morphogenesis [IMP]
- hemopoiesis [IMP]
- homeostasis of number of cells within a tissue [IMP]
- immune system development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- kidney development [IGI, IMP]
- leukocyte homeostasis [IMP]
- lymphocyte homeostasis [IGI, IMP]
- lymphoid progenitor cell differentiation [IMP]
- male gonad development [IGI]
- melanin metabolic process [IMP]
- melanocyte differentiation [IGI, IMP]
- mesenchymal cell development [IMP]
- metanephros development [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA, IMP]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO, ISS]
- negative regulation of apoptotic signaling pathway [IDA, ISO]
- negative regulation of calcium ion transport into cytosol [IGI]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of cellular pH reduction [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IDA, IMP, ISO]
- negative regulation of ossification [IMP]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of retinal cell programmed cell death [IMP]
- neuron apoptotic process [IGI, IMP]
- oocyte development [IMP]
- organ growth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- ovarian follicle development [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pigment granule organization [IMP]
- pigmentation [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of developmental pigmentation [IGI, IMP]
- positive regulation of melanocyte differentiation [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of neuron maturation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of skeletal muscle fiber development [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- post-embryonic development [IGI, IMP]
- protein dephosphorylation [IDA]
- protein polyubiquitination [ISO]
- reactive oxygen species metabolic process [IMP]
- regulation of apoptotic process [IGI]
- regulation of calcium ion transport [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell cycle [IMP]
- regulation of cell-matrix adhesion [IMP]
- regulation of developmental pigmentation [IGI]
- regulation of gene expression [IMP]
- regulation of glycoprotein biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of nitrogen utilization [IGI]
- regulation of programmed cell death [IGI]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein homodimerization activity [ISO]
- regulation of protein localization [IMP]
- regulation of protein stability [IMP]
- regulation of transmembrane transporter activity [ISO]
- regulation of viral genome replication [IDA]
- release of cytochrome c from mitochondria [IDA]
- renal system process [IMP]
- response to UV-B [IMP]
- response to acid chemical [IDA]
- response to cytokine [IMP, ISO]
- response to drug [IDA, ISO]
- response to gamma radiation [IMP]
- response to glucocorticoid [IDA, IMP]
- response to hydrogen peroxide [IMP]
- response to iron ion [ISO]
- response to ischemia [IMP]
- response to nicotine [ISO]
- response to oxidative stress [IMP]
- response to steroid hormone [IMP]
- response to toxic substance [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- spleen development [IGI, IMP]
- thymus development [IGI, IMP]
- transmembrane transport [ISO]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- endoplasmic reticulum [IDA, IGI, ISO]
- endoplasmic reticulum membrane [IDA]
- intracellular [IDA, IMP]
- membrane [IDA, ISO]
- mitochondrial membrane [IDA]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nuclear membrane [IDA, ISO]
- nucleus [IDA, ISO]
- pore complex [ISO]
Mus musculus
PREY
BNIP3
Nip3
BCL2/adenovirus E1B interacting protein 3
GO Process (26)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- apoptotic process [ISO]
- autophagic cell death [ISO]
- brown fat cell differentiation [IDA]
- cell death [ISO]
- cellular response to cobalt ion [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to hypoxia [ISO]
- defense response to virus [ISO]
- granzyme-mediated apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway [IGI, IMP]
- intrinsic apoptotic signaling pathway in response to hypoxia [ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrial outer membrane permeabilization [IBA, ISO]
- mitochondrial protein catabolic process [ISO]
- negative regulation of membrane potential [ISO]
- negative regulation of mitochondrial fusion [ISO]
- neuron apoptotic process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of mitochondrial fission [ISO]
- positive regulation of programmed cell death [IBA, ISO]
- positive regulation of protein complex disassembly [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of mitochondrial membrane permeability [ISO]
- response to hypoxia [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [ISO]
- dendrite [ISO]
- endoplasmic reticulum [IBA]
- integral component of mitochondrial outer membrane [ISO]
- intracellular [IGI]
- mitochondrial membrane [IDA, ISO]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [IBA, ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and ... [more]
J. Biol. Chem. Apr. 18, 2008; 283(16);10892-903 [Pubmed: 18281291]
Throughput
- Low Throughput
Curated By
- BioGRID