BAIT

ABL2

ABLL, ARG, RP11-177A2.3
ABL proto-oncogene 2, non-receptor tyrosine kinase
Homo sapiens
PREY

GRB2

ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
growth factor receptor-bound protein 2
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

c-Abl kinase regulates the protein binding activity of c-Crk.

Feller SM, Knudsen B, Hanafusa H

c-Crk is a proto-oncogene product composed largely of Src homology (SH) 2 and 3 domains. We have identified a kinase activity, which binds to the first Crk SH3 domain and phosphorylates c-Crk on tyrosine 221 (Y221), as c-Abl. c-Abl has a strong preference for c-Crk, when compared with common tyrosine kinase substrates. The phosphorylation of c-Crk Y221 creates a binding ... [more]

EMBO J. May. 15, 1994; 13(10);2341-51 [Pubmed: 8194526]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ABL2 GRB2
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9591BioGRID
3548990

Curated By

  • BioGRID