AKT2
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- cellular response to insulin stimulus [IMP]
- fat cell differentiation [TAS]
- insulin receptor signaling pathway [IMP, TAS]
- intracellular protein transmembrane transport [ISS]
- mammary gland epithelial cell differentiation [TAS]
- membrane organization [TAS]
- negative regulation of plasma membrane long-chain fatty acid transport [IMP]
- positive regulation of cell motility [IMP]
- positive regulation of fatty acid beta-oxidation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of glycogen biosynthetic process [IMP]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of protein targeting to membrane [ISS]
- positive regulation of vesicle fusion [ISS]
- regulation of cell cycle arrest [TAS]
- regulation of cell migration [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell cortex [ISS]
- cytosol [TAS]
- nucleus [IDA, TAS]
- plasma membrane [ISS, TAS]
- ruffle membrane [ISS]
CLIP3
Gene Ontology Biological Process
- chaperone-mediated protein transport [IMP]
- fat cell differentiation [ISS]
- membrane biogenesis [IMP]
- negative regulation of microtubule polymerization [IMP]
- peptidyl-L-cysteine S-palmitoylation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose transport [ISS]
- positive regulation of protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.
Akt is activated on the plasma membrane and its substrates are distributed throughout various cellular compartments. To phosphorylate its substrates, Akt needs to be recruited to specific intracellular compartments. Thus, regulation of Akt cellular compartmentalization constitutes an important mechanism to specify Akt signaling. Here, we report the identification of ClipR-59 as an Akt interaction protein. We show that the interaction ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CLIP3 AKT2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
CLIP3 AKT2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID