PDCD6
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- cellular response to heat [IDA]
- intracellular protein transport [IDA]
- negative regulation of TOR signaling [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- proteolysis [IBA]
- response to calcium ion [ISS]
- vascular endothelial growth factor receptor-2 signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAPK1
Gene Ontology Biological Process
- apoptotic process [IGI, IMP, TAS]
- apoptotic signaling pathway [IMP]
- cellular response to interferon-gamma [IDA]
- intracellular signal transduction [IDA]
- negative regulation of translation [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- protein autophosphorylation [IDA, TAS]
- protein phosphorylation [IDA, TAS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of apoptotic process [IBA, TAS]
- regulation of autophagy [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway.
Programmed cell death 6 (PDCD6) protein is a 22 kDa EF-hand type Ca(2+)-binding protein involved in apoptosis. To define the regulating mechanism of PDCD6 activity in the apoptotic pathway, we searched a human ovary cDNA library for a novel PDCD6 binding protein using a yeast two-hybrid system. The selected protein was the human death-associated protein kinase 1 (DAPk1), another protein ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDCD6 DAPK1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID