BAIT
AKT1
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1
GO Process (73)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- RNA metabolic process [TAS]
- T cell costimulation [TAS]
- activation-induced cell death of T cells [IMP]
- apoptotic process [TAS]
- blood coagulation [TAS]
- cell differentiation [TAS]
- cell proliferation [TAS]
- cellular protein modification process [TAS]
- cellular response to insulin stimulus [IMP, ISS]
- endocrine pancreas development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IMP]
- insulin-like growth factor receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- mammary gland epithelial cell differentiation [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of autophagy [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- negative regulation of endopeptidase activity [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- negative regulation of fatty acid beta-oxidation [IMP]
- negative regulation of neuron death [NAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [NAS]
- negative regulation of plasma membrane long-chain fatty acid transport [IMP]
- negative regulation of protein kinase activity [IMP, ISS]
- negative regulation of proteolysis [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nitric oxide biosynthetic process [TAS]
- nitric oxide metabolic process [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cellular protein metabolic process [ISS]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of glycogen biosynthetic process [IMP, NAS]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- protein autophosphorylation [TAS]
- protein import into nucleus, translocation [IMP]
- protein phosphorylation [IDA]
- regulation of cell cycle checkpoint [TAS]
- regulation of cell migration [IMP, TAS]
- regulation of glycogen biosynthetic process [IMP]
- regulation of neuron projection development [ISS]
- regulation of nitric-oxide synthase activity [TAS]
- response to UV-A [IDA]
- response to fluid shear stress [IMP]
- response to heat [TAS]
- response to oxidative stress [ISS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IC, IDA]
- enzyme binding [ISS]
- identical protein binding [IPI]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [IMP]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- phosphatidylinositol-3,4-bisphosphate binding [IDA]
- protein binding [IPI]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [IDA, TAS]
- protein serine/threonine/tyrosine kinase activity [IDA]
- 14-3-3 protein binding [IPI]
- ATP binding [IC, IDA]
- enzyme binding [ISS]
- identical protein binding [IPI]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [IMP]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- phosphatidylinositol-3,4-bisphosphate binding [IDA]
- protein binding [IPI]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [IDA, TAS]
- protein serine/threonine/tyrosine kinase activity [IDA]
Homo sapiens
PREY
FOXO1
AI876417, Afxh, FKHR, Fkhr1, Foxo1a
forkhead box O1
GO Process (29)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- blood vessel development [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to hyperoxia [ISO]
- cellular response to insulin stimulus [IDA]
- cellular response to nitric oxide [IDA]
- cellular response to oxidative stress [IDA]
- cellular response to starvation [ISO]
- glucose homeostasis [IDA]
- insulin receptor signaling pathway [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of stress-activated MAPK cascade [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neuronal stem cell maintenance [IGI]
- positive regulation of apoptotic process [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of gluconeogenesis [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell proliferation [IMP]
- regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of neural precursor cell proliferation [IGI]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of reactive oxygen species metabolic process [IGI]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IGI]
- protein binding [IPI]
- protein phosphatase 2A binding [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding transcription factor activity [IPI]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IGI]
- protein binding [IPI]
- protein phosphatase 2A binding [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding transcription factor activity [IPI]
- ubiquitin protein ligase binding [ISO]
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
Although genetic analysis has demonstrated that members of the winged helix, or forkhead, family of transcription factors play pivotal roles in the regulation of cellular differentiation and proliferation, both during development and in the adult, little is known of the mechanisms underlying their regulation. Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jun. 22, 1999; 96(13);7421-6 [Pubmed: 10377430]
Throughput
- Low Throughput
Curated By
- BioGRID