BAIT
BRCA1
BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53
breast cancer 1, early onset
GO Process (44)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [TAS]
- DNA repair [TAS]
- G2 DNA damage checkpoint [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to tumor necrosis factor [IMP]
- chordate embryonic development [IBA]
- chromosome segregation [IMP]
- dosage compensation by inactivation of X chromosome [IBA]
- double-strand break repair [IMP, TAS]
- double-strand break repair via homologous recombination [IDA, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of centriole replication [NAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fatty acid biosynthetic process [IMP]
- negative regulation of histone H3-K9 methylation [IDA]
- negative regulation of histone acetylation [IBA]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of DNA repair [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of histone H3-K9 acetylation [IDA]
- positive regulation of histone H4-K16 acetylation [IDA]
- positive regulation of histone H4-K20 methylation [IDA]
- positive regulation of histone acetylation [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [NAS, TAS]
- positive regulation vascular endothelial growth factor production [IMP]
- postreplication repair [IDA]
- protein K6-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of apoptotic process [TAS]
- regulation of cell proliferation [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase III promoter [TAS]
- response to estrogen [IDA]
- response to ionizing radiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SSN3
CDK8, GIG2, NUT7, RYE5, SRB10, SSX7, UME5, URR1, cyclin-dependent serine/threonine protein kinase SSN3, L000002795, S000029631, L000002443, S000029520, L000002103, YPL042C
Cyclin-dependent protein kinase; component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
GO Process (7)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of filamentous growth [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, IPI]
- nuclear-transcribed mRNA catabolic process, non-stop decay [IMP]
- phosphorylation of RNA polymerase II C-terminal domain [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter by galactose [IMP]
- protein destabilization [IMP]
- protein phosphorylation [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 ... [more]
PLoS ONE Jan. 17, 2008; 3(1);e1448 [Pubmed: 18197258]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Curated By
- BioGRID