BAIT
PCSK9
FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, PSEC0052
proprotein convertase subtilisin/kexin type 9
GO Process (17)
GO Function (11)
GO Component (11)
Gene Ontology Biological Process
- cellular response to insulin stimulus [ISS]
- cellular response to starvation [ISS]
- cholesterol homeostasis [IMP]
- kidney development [ISS]
- liver development [ISS]
- low-density lipoprotein particle receptor catabolic process [IDA]
- lysosomal transport [IDA]
- negative regulation of low-density lipoprotein particle clearance [IDA]
- negative regulation of receptor recycling [IDA]
- neurogenesis [ISS]
- neuron differentiation [ISS]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of receptor internalization [IDA]
- protein autoprocessing [IDA]
- proteolysis [IBA]
- regulation of neuron apoptotic process [ISS]
- regulation of receptor activity [IDA]
Gene Ontology Molecular Function- apolipoprotein binding [ISS]
- apolipoprotein receptor binding [IDA]
- low-density lipoprotein particle binding [ISS]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein self-association [IDA]
- serine-type endopeptidase activity [IDA]
- sodium channel inhibitor activity [IDA]
- very-low-density lipoprotein particle binding [ISS]
- very-low-density lipoprotein particle receptor binding [IDA]
- apolipoprotein binding [ISS]
- apolipoprotein receptor binding [IDA]
- low-density lipoprotein particle binding [ISS]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein self-association [IDA]
- serine-type endopeptidase activity [IDA]
- sodium channel inhibitor activity [IDA]
- very-low-density lipoprotein particle binding [ISS]
- very-low-density lipoprotein particle receptor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A12
AGC1, ARALAR
solute carrier family 25 (aspartate/glutamate carrier), member 12
GO Process (10)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- L-aspartate transmembrane transport [IDA]
- L-glutamate transmembrane transport [IDA]
- L-glutamate transport [IDA]
- aspartate transport [IDA]
- carbohydrate metabolic process [TAS]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- malate-aspartate shuttle [IDA]
- response to calcium ion [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway.
Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. However, how PCSK9 mediates LDLR degradation is still unknown. By combining a shotgun proteomic method and differential analysis of natural occurring mutations of the PCSK9 gene, we found that an E3 ubiquitin ligase ... [more]
Molecules Oct. 23, 2012; 17(10);12086-101 [Pubmed: 23085658]
Throughput
- Low Throughput
Additional Notes
- Table 1
Curated By
- BioGRID