PPARG
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cell fate commitment [ISS]
- cell maturation [IDA]
- cellular response to insulin stimulus [IMP]
- epithelial cell differentiation [ISS]
- gene expression [TAS]
- glucose homeostasis [IMP]
- innate immune response [TAS]
- lipid homeostasis [TAS]
- lipid metabolic process [TAS]
- lipoprotein transport [IDA]
- long-chain fatty acid transport [ISS]
- low-density lipoprotein particle receptor biosynthetic process [IDA]
- monocyte differentiation [IDA]
- negative regulation of cholesterol storage [IDA]
- negative regulation of interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of macrophage derived foam cell differentiation [IC, IDA]
- negative regulation of receptor biosynthetic process [IDA]
- negative regulation of sequestering of triglyceride [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- negative regulation of transcription, DNA-templated [ISS]
- peroxisome proliferator activated receptor signaling pathway [IMP]
- placenta development [ISS]
- positive regulation of fat cell differentiation [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of blood pressure [IMP]
- regulation of cholesterol transporter activity [IC]
- regulation of transcription involved in cell fate commitment [ISS]
- response to lipid [ISS]
- response to low-density lipoprotein particle [IDA]
- response to nutrient [TAS]
- response to retinoic acid [IDA]
- signal transduction [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- white fat cell differentiation [ISS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- activating transcription factor binding [IDA]
- arachidonic acid binding [ISS]
- chromatin binding [ISS]
- drug binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- prostaglandin receptor activity [TAS]
- protein binding [IPI]
- retinoid X receptor binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA, ISS]
- DNA binding [IDA, ISS]
- activating transcription factor binding [IDA]
- arachidonic acid binding [ISS]
- chromatin binding [ISS]
- drug binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- prostaglandin receptor activity [TAS]
- protein binding [IPI]
- retinoid X receptor binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA, ISS]
Gene Ontology Cellular Component
CDC34
Gene Ontology Biological Process
- DNA replication initiation [NAS]
- G1/S transition of mitotic cell cycle [NAS]
- cellular protein modification process [NAS]
- negative regulation of cAMP-mediated signaling [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K48-linked ubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
PPARγ E3 ubiquitin ligase regulates MUC1-C oncoprotein stability.
MUC1-C oncoprotein is associated with colon, breast, ovarian, lung and pancreatic cancers. MUC1-C interacts with intracellular proteins to elicit signaling cascades that induce cell proliferation and tumor growth. Here we report that peroxisome proliferator-activated receptor gamma (PPARγ), an E3 ubiquitin ligase, is an inhibitor of MUC1-C-mediated cell proliferation. PPARγ does so by binding to and inducing MUC1-C proteasome-dependent degradation that ... [more]
Throughput
- Low Throughput
Additional Notes
- E2:UbcH3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPARG CDC34 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID