BAIT
SIRT1
SIR2L1, RP11-57G10.3
sirtuin 1
GO Process (87)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- DNA repair [TAS]
- DNA replication [TAS]
- DNA synthesis involved in DNA repair [ISS]
- angiogenesis [IDA]
- cell aging [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to hypoxia [IMP]
- cellular response to ionizing radiation [ISS]
- cellular response to starvation [ISS]
- cellular response to tumor necrosis factor [IDA]
- cellular triglyceride homeostasis [ISS]
- cholesterol homeostasis [ISS]
- chromatin organization [IMP]
- chromatin silencing [TAS]
- chromatin silencing at rDNA [IDA]
- circadian regulation of gene expression [IMP, ISS]
- establishment of chromatin silencing [IDA]
- fatty acid homeostasis [ISS]
- histone H3 deacetylation [IDA, IMP]
- histone H3-K9 modification [ISS]
- histone deacetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- maintenance of chromatin silencing [IMP]
- methylation-dependent chromatin silencing [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of androgen receptor signaling pathway [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cAMP-dependent protein kinase activity [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of cellular response to testosterone stimulus [IMP]
- negative regulation of cellular senescence [IDA]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of helicase activity [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of peptidyl-lysine acetylation [IDA]
- negative regulation of phosphorylation [IMP]
- negative regulation of prostaglandin biosynthetic process [ISS]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISS]
- peptidyl-lysine acetylation [IMP]
- peptidyl-lysine deacetylation [IDA]
- positive regulation of DNA repair [IMP]
- positive regulation of MHC class II biosynthetic process [IDA]
- positive regulation of adaptive immune response [IDA]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of cAMP-dependent protein kinase activity [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular senescence [IDA]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of chromatin silencing [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of histone H3-K9 methylation [IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of macroautophagy [IDA]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ADP-ribosylation [TAS]
- protein deacetylation [IDA, IMP]
- protein destabilization [ISS]
- protein ubiquitination [IDA]
- pyrimidine dimer repair by nucleotide-excision repair [IMP]
- regulation of bile acid biosynthetic process [ISS]
- regulation of cell proliferation [IMP]
- regulation of endodeoxyribonuclease activity [IMP]
- regulation of glucose metabolic process [ISS]
- regulation of mitotic cell cycle [IDA]
- regulation of peroxisome proliferator activated receptor signaling pathway [ISS]
- regulation of protein import into nucleus, translocation [IMP]
- regulation of smooth muscle cell apoptotic process [ISS]
- response to endoplasmic reticulum stress [ISS]
- response to hydrogen peroxide [IDA]
- response to insulin [ISS]
- response to oxidative stress [IDA]
- single strand break repair [IMP]
- triglyceride mobilization [ISS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function- HLH domain binding [IPI]
- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [ISS]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- bHLH transcription factor binding [IPI]
- deacetylase activity [IDA]
- enzyme binding [IPI]
- histone binding [IPI]
- histone deacetylase activity [IDA]
- identical protein binding [IPI]
- keratin filament binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- p53 binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA]
- transcription corepressor activity [IDA, ISS]
- transcription factor binding [IPI]
- HLH domain binding [IPI]
- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [ISS]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- bHLH transcription factor binding [IPI]
- deacetylase activity [IDA]
- enzyme binding [IPI]
- histone binding [IPI]
- histone deacetylase activity [IDA]
- identical protein binding [IPI]
- keratin filament binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- p53 binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA]
- transcription corepressor activity [IDA, ISS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- ESC/E(Z) complex [IDA]
- PML body [IDA]
- chromatin silencing complex [IDA]
- cytoplasm [IDA]
- mitochondrion [IDA]
- nuclear chromatin [IDA]
- nuclear envelope [IDA]
- nuclear euchromatin [IDA]
- nuclear heterochromatin [IDA]
- nuclear inner membrane [IDA]
- nucleolus [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- rDNA heterochromatin [IDA]
Homo sapiens
PREY
UBE2I
C358B7.1, P18, UBC9, LA16c-358B7.1
ubiquitin-conjugating enzyme E2I
GO Process (8)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Biochemical Activity (Deacetylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular signalling mechanisms that differentially regulate substrate sumoylation. Here, we show that acetylation of SUMO E2 conjugase Ubc9 selectively downregulates the sumoylation of substrates with negatively charged amino acid-dependent sumoylation motif (NDSM) consisting of clustered acidic residues located downstream from the core ψ-K-X-E/D ... [more]
EMBO J. Mar. 20, 2013; 32(6);791-804 [Pubmed: 23395904]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Curated By
- BioGRID