BAIT
EIF4EBP1
4E-BP1, 4EBP1, BP-1, PHAS-I
eukaryotic translation initiation factor 4E binding protein 1
GO Process (9)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- TOR signaling [IDA]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of translational initiation [IDA]
- positive regulation of mitotic cell cycle [IMP]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
TCF4
E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19
transcription factor 4
GO Process (6)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [ISS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- protein-DNA complex assembly [ISS]
- transcription initiation from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Cell Nov. 20, 2014; 159(5);1212-26 [Pubmed: 25416956]
Throughput
- High Throughput
Curated By
- BioGRID