SHMT2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CREB3
Gene Ontology Biological Process
- cytoplasmic sequestering of transcription factor [IDA]
- establishment of viral latency [IDA]
- induction of positive chemotaxis [IDA, IMP]
- negative regulation of cell cycle [NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of deacetylase activity [IDA]
- positive regulation of defense response to virus by host [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell growth [IDA]
- regulation of cell proliferation [IMP]
- release from viral latency [IDA, TAS]
- response to endoplasmic reticulum stress [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [IMP]
- Golgi membrane [IDA]
- cytoplasm [IDA, IMP]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- membrane [IDA]
- neuronal cell body [IDA]
- nuclear body [IDA]
- nucleus [IC, IDA]
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a systematic, unbiased, and comprehensive approach, termed "interactome capture," to define the mRNA interactome of proliferating human HeLa cells. We identify 860 proteins that qualify as RBPs by biochemical and statistical criteria, adding more than 300 ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CREB3 SHMT2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID