PPARG
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cell fate commitment [ISS]
- cell maturation [IDA]
- cellular response to insulin stimulus [IMP]
- epithelial cell differentiation [ISS]
- gene expression [TAS]
- glucose homeostasis [IMP]
- innate immune response [TAS]
- lipid homeostasis [TAS]
- lipid metabolic process [TAS]
- lipoprotein transport [IDA]
- long-chain fatty acid transport [ISS]
- low-density lipoprotein particle receptor biosynthetic process [IDA]
- monocyte differentiation [IDA]
- negative regulation of cholesterol storage [IDA]
- negative regulation of interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of macrophage derived foam cell differentiation [IC, IDA]
- negative regulation of receptor biosynthetic process [IDA]
- negative regulation of sequestering of triglyceride [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- negative regulation of transcription, DNA-templated [ISS]
- peroxisome proliferator activated receptor signaling pathway [IMP]
- placenta development [ISS]
- positive regulation of fat cell differentiation [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of blood pressure [IMP]
- regulation of cholesterol transporter activity [IC]
- regulation of transcription involved in cell fate commitment [ISS]
- response to lipid [ISS]
- response to low-density lipoprotein particle [IDA]
- response to nutrient [TAS]
- response to retinoic acid [IDA]
- signal transduction [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- white fat cell differentiation [ISS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- activating transcription factor binding [IDA]
- arachidonic acid binding [ISS]
- chromatin binding [ISS]
- drug binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- prostaglandin receptor activity [TAS]
- protein binding [IPI]
- retinoid X receptor binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA, ISS]
- DNA binding [IDA, ISS]
- activating transcription factor binding [IDA]
- arachidonic acid binding [ISS]
- chromatin binding [ISS]
- drug binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- prostaglandin receptor activity [TAS]
- protein binding [IPI]
- retinoid X receptor binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA, ISS]
Gene Ontology Cellular Component
GRIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects.
Rosiglitazone displays powerful antidiabetes benefits but is associated with increased body weight and adipogenesis. Keeping in mind the concept of selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, the aim of this study was to characterize the properties of a new PPARgamma ligand, S 26948, with special attention in body-weight gain.We used transient transfection and binding assays to characterized the binding characteristics ... [more]
Throughput
- Low Throughput
Additional Notes
- PPAR-gamma is definitely human, but the source of the other protein is not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIP1 PPARG | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 1055658 | |
| PPARG GRIP1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID