CD63
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell migration [IMP]
- cell-matrix adhesion [IMP]
- cellular protein localization [IDA]
- endosome to melanosome transport [IMP]
- pigment granule maturation [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of integrin-mediated signaling pathway [IMP]
- positive regulation of receptor internalization [IMP]
- regulation of rubidium ion transport [IDA]
- regulation of vascular endothelial growth factor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- endosome lumen [IDA]
- endosome membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intrinsic component of plasma membrane [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- multivesicular body, internal vesicle [IDA]
- plasma membrane [TAS]
- platelet dense granule membrane [TAS]
SDCBP
Gene Ontology Biological Process
- actin cytoskeleton organization [NAS]
- axon guidance [TAS]
- intracellular signal transduction [NAS]
- positive regulation of JNK cascade [IC]
- positive regulation of exosomal secretion [IMP]
- positive regulation of extracellular vesicular exosome assembly [IMP]
- positive regulation of phosphorylation [IDA]
- protein targeting to membrane [NAS]
- substrate-dependent cell migration, cell extension [NAS]
- synaptic transmission [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
The biogenesis of exosomes, small secreted vesicles involved in signalling processes, remains incompletely understood. Here, we report evidence that the syndecan heparan sulphate proteoglycans and their cytoplasmic adaptor syntenin control the formation of exosomes. Syntenin interacts directly with ALIX through LYPX(n)L motifs, similarly to retroviral proteins, and supports the intraluminal budding of endosomal membranes. Syntenin exosomes depend on the availability ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD63 SDCBP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID