BAIT
PYCARD
ASC, CARD5, TMS, TMS-1, TMS1
PYD and CARD domain containing
GO Process (48)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [NAS]
- activation of innate immune response [IDA]
- apoptotic process [TAS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- defense response to Gram-negative bacterium [IMP]
- defense response to virus [IDA]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- macropinocytosis [ISS]
- myeloid dendritic cell activation [IMP]
- myeloid dendritic cell activation involved in immune response [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of interferon-beta production [IMP]
- negative regulation of protein serine/threonine kinase activity [IDA]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell migration [ISS]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of activated T cell proliferation [ISS]
- positive regulation of adaptive immune response [IMP]
- positive regulation of antigen processing and presentation of peptide antigen via MHC class II [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of chemokine secretion [IMP]
- positive regulation of cysteine-type endopeptidase activity [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-1 beta secretion [IDA]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-6 production [ISS]
- positive regulation of interleukin-6 secretion [IMP]
- positive regulation of interleukin-8 secretion [IMP]
- positive regulation of phagocytosis [ISS]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of intrinsic apoptotic signaling pathway [IDA]
- regulation of protein stability [ISS]
- regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- signal transduction [NAS]
- tumor necrosis factor-mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BMPR2
BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (30)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
The apoptosis-associated speck-like protein containing a caspase-activating recruitment domain (ASC) is an essential component of several inflammasomes, multiprotein complexes that regulate caspase-1 activation and inflammation. We report here an interaction between promyelocytic leukemia protein (PML) and ASC. We observed enhanced formation of ASC dimers in PML-deficient macrophages. These macrophages also display enhanced levels of ASC in the cytosol. Furthermore, IL-1β ... [more]
J. Biol. Chem. Mar. 07, 2014; 289(10);6429-37 [Pubmed: 24407287]
Throughput
- High Throughput
Curated By
- BioGRID