BAIT
CSNK2A2
CK2A2, CSNK2A1
casein kinase 2, alpha prime polypeptide
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SIRT1
AA673258, SIR2L1, Sir2, Sir2a, Sir2alpha
sirtuin 1
GO Process (101)
GO Function (21)
GO Component (18)
Gene Ontology Biological Process
- DNA synthesis involved in DNA repair [IMP]
- angiogenesis [ISO]
- behavioral response to starvation [IMP]
- cellular glucose homeostasis [IMP]
- cellular response to DNA damage stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to hypoxia [ISO]
- cellular response to ionizing radiation [IMP]
- cellular response to starvation [IMP]
- cellular response to tumor necrosis factor [ISO]
- cellular triglyceride homeostasis [IMP]
- cholesterol homeostasis [IMP]
- chromatin organization [ISO]
- chromatin silencing at rDNA [ISO]
- circadian regulation of gene expression [IMP, ISO]
- establishment of chromatin silencing [ISO]
- fatty acid homeostasis [IMP]
- histone H3 deacetylation [IDA, ISO]
- histone H3-K9 modification [IDA]
- histone deacetylation [IDA, IGI, ISA, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- maintenance of chromatin silencing [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of TOR signaling [IMP, ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cAMP-dependent protein kinase activity [ISO]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cellular response to testosterone stimulus [ISO]
- negative regulation of cellular senescence [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast apoptotic process [ISO]
- negative regulation of growth hormone secretion [ISO]
- negative regulation of helicase activity [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of neuron death [IGI]
- negative regulation of nucleic acid-templated transcription [IMP]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of peptidyl-lysine acetylation [ISO]
- negative regulation of phosphorylation [IMP, ISO]
- negative regulation of prostaglandin biosynthetic process [IMP]
- negative regulation of protein kinase B signaling [IMP, ISO]
- negative regulation of reactive oxygen species biosynthetic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- negative regulation of tumor necrosis factor production [ISO]
- ovulation from ovarian follicle [IMP]
- peptidyl-lysine acetylation [ISO]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of MHC class II biosynthetic process [ISO]
- positive regulation of adaptive immune response [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cAMP-dependent protein kinase activity [IDA, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular senescence [ISO]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of chromatin silencing [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of gluconeogenesis [ISO]
- positive regulation of heart rate [ISO]
- positive regulation of histone H3-K9 methylation [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of macroautophagy [IDA, ISO]
- positive regulation of macrophage apoptotic process [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of skeletal muscle cell proliferation [ISO]
- positive regulation of thyroid-stimulating hormone secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of vasodilation [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein deacetylation [IDA, IMP, ISO]
- protein destabilization [IDA]
- protein ubiquitination [ISO]
- pyrimidine dimer repair by nucleotide-excision repair [IMP, ISO]
- regulation of bile acid biosynthetic process [IMP]
- regulation of cell proliferation [ISO]
- regulation of endodeoxyribonuclease activity [ISO]
- regulation of energy homeostasis [ISO]
- regulation of glucose metabolic process [IMP]
- regulation of mitotic cell cycle [ISO]
- regulation of peroxisome proliferator activated receptor signaling pathway [IMP]
- regulation of protein import into nucleus, translocation [ISO]
- regulation of smooth muscle cell apoptotic process [IDA]
- response to ethanol [ISO]
- response to hydrogen peroxide [ISO]
- response to insulin [IDA]
- response to oxidative stress [ISO]
- single strand break repair [ISO]
- spermatogenesis [IMP]
- triglyceride mobilization [IMP]
- white fat cell differentiation [IMP]
Gene Ontology Molecular Function- HLH domain binding [ISO]
- NAD-dependent histone deacetylase activity [IDA, ISA, ISO]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, ISO]
- bHLH transcription factor binding [ISO]
- core promoter sequence-specific DNA binding [IDA]
- deacetylase activity [IMP, ISO]
- enzyme binding [IPI, ISO]
- histone binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- keratin filament binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- p53 binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- protein domain specific binding [IPI]
- protein kinase B binding [ISO]
- transcription corepressor activity [IMP, ISO]
- transcription factor binding [ISO]
- HLH domain binding [ISO]
- NAD-dependent histone deacetylase activity [IDA, ISA, ISO]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, ISO]
- bHLH transcription factor binding [ISO]
- core promoter sequence-specific DNA binding [IDA]
- deacetylase activity [IMP, ISO]
- enzyme binding [IPI, ISO]
- histone binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- keratin filament binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- p53 binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- protein domain specific binding [IPI]
- protein kinase B binding [ISO]
- transcription corepressor activity [IMP, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- ESC/E(Z) complex [ISO]
- PML body [ISO]
- axon [ISO]
- cell [IMP]
- chromatin [IDA]
- chromatin silencing complex [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- growth cone [ISO]
- mitochondrion [ISO]
- nuclear chromatin [ISO]
- nuclear envelope [ISO]
- nuclear euchromatin [ISO]
- nuclear heterochromatin [IDA, ISO]
- nuclear inner membrane [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- rDNA heterochromatin [ISO]
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
SIRT1, an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase, protects cells from stress-induced apoptosis, and its orthologues delay aging in lower eukaryotes. SIRT1 increases survival in response to stress such as DNA damage by deacetylating a number of substrates including pro-apoptotic protein p53. The molecular mechanism by which DNA-damage activates SIRT1 is not known. By screening a kinase inhibitor library, we identified ... [more]
PLoS ONE Aug. 15, 2009; 4(8);e6611 [Pubmed: 19680552]
Throughput
- Low Throughput
Curated By
- BioGRID