BAIT
FBXW8
FBW6, FBW8, FBX29, FBXO29, FBXW6
F-box and WD repeat domain containing 8
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TCP1
CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha
t-complex 1
GO Process (4)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Characterization of the Cullin7 E3 ubiquitin ligase - Heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.
Cul1 and Cul7 are cullin E3 ubiquitin ligase scaffold proteins. Cul1 is known to form a complex with the RING domain protein Rbx1 and one of approximately 70 different F-box proteins. F-box proteins function as substrate receptor subunits and recruit numerous substrates for poly-ubiquitination. Similarly to Cul1, Cul7 interacts with Rbx1, however, only one F-box protein, Fbxw8, has been shown ... [more]
Cell. Signal. Jan. 01, 2012; 24(1);290-5 [Pubmed: 21946088]
Throughput
- Low Throughput
Curated By
- BioGRID