CDK2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA replication [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [NAS, TAS]
- Ras protein signal transduction [IEP]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- blood coagulation [TAS]
- cellular response to nitric oxide [TAS]
- centrosome duplication [TAS]
- histone phosphorylation [IDA]
- meiotic nuclear division [TAS]
- mitotic G1 DNA damage checkpoint [TAS]
- mitotic cell cycle [TAS]
- positive regulation of cell proliferation [IDA]
- regulation of gene silencing [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SCN5A
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [IMP]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- brainstem development [ISS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cardiac muscle cell action potential involved in contraction [IMP]
- cardiac muscle contraction [IMP]
- cardiac ventricle development [ISS]
- cellular response to calcium ion [IDA]
- cerebellum development [ISS]
- membrane depolarization [IDA]
- membrane depolarization during SA node cell action potential [ISS]
- membrane depolarization during action potential [IDA]
- membrane depolarization during cardiac muscle cell action potential [IMP]
- neuronal action potential [IBA]
- odontogenesis of dentin-containing tooth [ISS]
- positive regulation of action potential [ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of sodium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of atrial cardiac muscle cell membrane repolarization [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of sodium ion transmembrane transport [IDA]
- regulation of ventricular cardiac muscle cell membrane depolarization [IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- response to denervation involved in regulation of muscle adaptation [ISS]
- sodium ion transmembrane transport [IDA, IMP]
- sodium ion transport [IDA]
- telencephalon development [ISS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- ankyrin binding [IDA]
- calmodulin binding [IPI]
- enzyme binding [IPI]
- fibroblast growth factor binding [IPI]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IDA, IMP]
- ankyrin binding [IDA]
- calmodulin binding [IPI]
- enzyme binding [IPI]
- fibroblast growth factor binding [IPI]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IDA, IMP]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity.
HER2/neu oncogene is frequently deregulated in cancers, and the (PI3K)-Akt signaling is one of the major pathways in mediating HER2/neu oncogenic signal. p57 (Kip2) , an inhibitor of cyclin-depependent kinases, is pivotal in regulating cell cycle progression, but its upstream regulators remain unclear. Here we show that the HER2-Akt axis is linked to p57 (Kip2) regulation, and that Akt is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID