HHP1
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [ISO]
- homologous chromosome segregation [IGI]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-threonine autophosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- protein phosphorylation [ISO]
- regulation of DNA repair [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HHP2
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [ISO]
- homologous chromosome segregation [IGI]
- negative regulation of ergosterol biosynthetic process [IMP]
- negative regulation of transcription by transcription factor catabolism [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- protein autophosphorylation [IDA]
- regulation of DNA repair [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CK1 Is Required for a Mitotic Checkpoint that Delays Cytokinesis.
Failure to accurately partition genetic material during cell division causes aneuploidy and drives tumorigenesis [1]. Cell-cycle checkpoints safeguard cells from such catastrophes by impeding cell-cycle progression when mistakes arise. FHA-RING E3 ligases, including human RNF8 [2] and CHFR [3] and fission yeast Dma1 [4], relay checkpoint signals by binding phosphorylated proteins via their FHA domains and promoting ubiquitination of downstream ... [more]
Throughput
- High Throughput
Additional Notes
- Figure 3D
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HHP2 HHP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1100559 | |
| HHP2 HHP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | PomBase | - | |
| HHP1 HHP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | PomBase | - | |
| HHP1 HHP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 300557 | |
| HHP1 HHP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2327756 | |
| HHP1 HHP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 448494 | |
| HHP1 HHP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| HHP2 HHP1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | PomBase | - | |
| HHP1 HHP2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 248193 |
Curated By
- BioGRID