HHP1
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [ISO]
- homologous chromosome segregation [IGI]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-threonine autophosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- protein phosphorylation [ISO]
- regulation of DNA repair [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HHP2
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [ISO]
- homologous chromosome segregation [IGI]
- negative regulation of ergosterol biosynthetic process [IMP]
- negative regulation of transcription by transcription factor catabolism [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- protein autophosphorylation [IDA]
- regulation of DNA repair [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.
Segregation of chromosomes during meiosis depends on separase cleavage of Rec8, the meiosis-specific alpha-kleisin subunit of cohesin. We mapped Rec8 phosphorylation sites by mass spectrometry and show that, in fission yeast, Rec8 phosphorylation is required for proper chromosome disjunction during meiosis. We further show that the fission yeast casein kinase 1 (CK1) delta/epsilon isoforms Hhp1 and Hhp2 are required for ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide modification (APO:0000131)
- phenotype: nuclear morphology (APO:0000057)
Additional Notes
- double mutants show a decrease in phosphorylation of Rec8
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HHP1 HHP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1100547 | |
| HHP2 HHP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1100559 | |
| HHP2 HHP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | PomBase | - | |
| HHP1 HHP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | PomBase | - | |
| HHP1 HHP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 300557 | |
| HHP1 HHP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2327756 | |
| HHP1 HHP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| HHP2 HHP1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | PomBase | - | |
| HHP1 HHP2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 248193 |
Curated By
- BioGRID