UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HIF1A
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- axon transport of mitochondrion [IMP]
- cellular response to hypoxia [IDA, IEP, TAS]
- cellular response to interleukin-1 [IEP]
- collagen metabolic process [ISS]
- connective tissue replacement involved in inflammatory response wound healing [ISS]
- elastin metabolic process [ISS]
- epithelial to mesenchymal transition [ISS]
- mRNA transcription from RNA polymerase II promoter [IC]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- oxygen homeostasis [IDA]
- positive regulation of angiogenesis [IC]
- positive regulation of chemokine production [TAS]
- positive regulation of chemokine-mediated signaling pathway [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of epithelial cell migration [ISS]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [TAS]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, IMP]
- regulation of gene expression [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- regulation of transcription, DNA-templated [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IDA, IMP]
- signal transduction [IMP]
- vascular endothelial growth factor production [IDA]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy.
The length and precise linkage of polyubiquitin chains is important for their biological activity. Although other ubiquitin-like proteins have the potential to form polymeric chains their identification in vivo is challenging and their functional role is unclear. Vertebrates express three small ubiquitin-like modifiers, SUMO-1, SUMO-2, and SUMO-3. Mature SUMO-2 and SUMO-3 are nearly identical and contain an internal consensus site ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 8
- in vitro-generated poly-sumo chains on HIF1a; SUMO1 and SUMO2 were source of SUMO
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBE2I HIF1A | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2459637 |
Curated By
- BioGRID