IKBKG
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- I-kappaB kinase/NF-kappaB signaling [TAS]
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [NAS, TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [IDA]
- establishment of vesicle localization [IMP]
- immune response [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- negative regulation of neuron death [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of type I interferon production [TAS]
- response to virus [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYD88
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- defense response to Gram-positive bacterium [ISS]
- innate immune response [TAS]
- negative regulation of apoptotic process [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of interleukin-17 production [ISS]
- positive regulation of interleukin-23 production [ISS]
- positive regulation of interleukin-6 production [ISS]
- positive regulation of type I interferon production [TAS]
- regulation of inflammatory response [ISS]
- response to interleukin-1 [IMP]
- signal transduction [NAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.
Polyubiquitin (pUb) chains formed between the C terminus of ubiquitin and lysine 63 (K63) or methionine 1 (M1) of another ubiquitin have been implicated in the activation of the canonical IκB kinase (IKK) complex. Here, we demonstrate that nearly all of the M1-pUb chains formed in response to interleukin-1, or the Toll-Like Receptors 1/2 agonist Pam3CSK4, are covalently attached to ... [more]
Throughput
- Low Throughput
Additional Notes
- Table S1
- identified via mass-spec
- when IL1 stimulated, dependent on ubiquitin-binding
Curated By
- BioGRID