INSR
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [ISO]
- activation of protein kinase B activity [ISO]
- activation of protein kinase activity [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to insulin stimulus [ISO]
- epidermis development [ISO]
- exocrine pancreas development [ISO]
- fat cell differentiation [IEP]
- glucose homeostasis [IDA, ISO]
- heart morphogenesis [ISO]
- insulin receptor signaling pathway [IDA, IMP, ISO]
- male sex determination [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of transporter activity [IMP]
- organ morphogenesis [ISO]
- peptidyl-tyrosine autophosphorylation [ISO]
- peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of developmental growth [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of glycoprotein biosynthetic process [IMP]
- positive regulation of mitosis [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of respiratory burst [ISO]
- protein autophosphorylation [IDA, IMP, ISO]
- protein heterotetramerization [IDA, ISO]
- protein phosphorylation [IDA]
- regulation of embryonic development [ISO]
- regulation of hydrogen peroxide metabolic process [IDA]
- regulation of transcription, DNA-templated [ISO]
- response to activity [IEP]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to glucocorticoid [IEP]
- response to glucose [IEP]
- response to hormone [IEP]
- response to insulin [IEP]
- response to manganese ion [IEP]
- response to nutrient levels [IEP]
- response to testosterone [IEP]
- response to tumor necrosis factor [IMP]
- response to vitamin D [IEP]
- signal transduction by phosphorylation [ISO]
- transformation of host cell by virus [ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [IDA]
- ATP binding [ISO]
- GTP binding [ISO]
- PTB domain binding [ISO]
- insulin binding [IDA, IMP, ISO]
- insulin receptor substrate binding [IMP, ISO]
- insulin-activated receptor activity [IDA, IMP, ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor II binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- lipoic acid binding [IPI]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein domain specific binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [IPI]
- protein phosphatase binding [IMP]
- protein tyrosine kinase activity [IDA, ISO]
- receptor signaling protein tyrosine kinase activity [ISO]
- 3-phosphoinositide-dependent protein kinase binding [IDA]
- ATP binding [ISO]
- GTP binding [ISO]
- PTB domain binding [ISO]
- insulin binding [IDA, IMP, ISO]
- insulin receptor substrate binding [IMP, ISO]
- insulin-activated receptor activity [IDA, IMP, ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor II binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- lipoic acid binding [IPI]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein domain specific binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [IPI]
- protein phosphatase binding [IMP]
- protein tyrosine kinase activity [IDA, ISO]
- receptor signaling protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
ARCN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The last enzyme of the de novo purine synthesis pathway ATIC plays a central role in insulin signalling and the Golgi/endosomes protein network.
Insulin is internalized with its cognate receptor into the endosomal apparatus rapidly after binding to hepatocytes. We performed a bioinformatic screen of Golgi/endosome (G/E) hepatic protein fractions and found that ATIC, which is a rate limiting enzyme in the de novo purine biosynthesis pathway, and PTPLAD1 are associated with IR internalisation. The IR interactome (IRGEN) connects ATIC to AMPK within ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| INSR ARCN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID