FES
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [IBA]
- cell proliferation [TAS]
- chemotaxis [IBA]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- multicellular organismal development [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of actin cytoskeleton reorganization [IMP]
- positive regulation of microtubule polymerization [IMP]
- positive regulation of myeloid cell differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of cell adhesion [IMP]
- regulation of cell differentiation [IMP]
- regulation of cell motility [IMP]
- regulation of cell proliferation [IMP]
- regulation of cell shape [IMP]
- regulation of mast cell degranulation [IMP]
- regulation of vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DSP
Gene Ontology Biological Process
- apoptotic process [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- desmosome organization [ISS]
- epidermis development [TAS]
- intermediate filament organization [ISS]
- keratinocyte differentiation [IDA]
- peptide cross-linking [IDA]
- protein localization to adherens junction [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular compact myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells rather than in normal cells. The acquisition of resistance in cells exposed to TRAIL or its mimics limits their clinical efficacy. Because kinases are intimately involved in the regulation of apoptosis, we systematically characterized kinases involved in TRAIL signaling. ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FES DSP | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 24.7273 | BioGRID | 3481216 |
Curated By
- BioGRID