STK11
Gene Ontology Biological Process
- activation of protein kinase activity [IDA]
- anoikis [IMP]
- cell cycle arrest [IDA, TAS]
- energy reserve metabolic process [TAS]
- establishment of cell polarity [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IDA]
- negative regulation of cell growth [ISS]
- negative regulation of cell proliferation [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of cell growth [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- response to ionizing radiation [ISS]
- small molecule metabolic process [TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
WDR6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.
Germline mutations of the serine/threonine kinase LKB1 (also known as STK11) lead to Peutz-Jeghers syndrome (PJS) that is associated with increased incidence of malignant cancers. However, the tumor suppressor function of LKB1 has not been fully elucidated. We applied yeast two-hybrid screening and identified that a novel WD-repeat protein WDR6 was able to interact with LKB1. Immunofluorescence staining revealed that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID