ATXN3
Gene Ontology Biological Process
- actin cytoskeleton organization [ISO]
- cellular response to heat [IMP]
- cellular response to misfolded protein [IMP]
- exploration behavior [IMP]
- intermediate filament cytoskeleton organization [ISO]
- microtubule cytoskeleton organization [ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP]
- monoubiquitinated protein deubiquitination [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K48-linked deubiquitination [ISO]
- protein K63-linked deubiquitination [ISO]
- proteolysis [ISO]
- regulation of cell-substrate adhesion [IMP, ISO]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- Lys48-specific deubiquitinase activity [ISO]
- Lys63-specific deubiquitinase activity [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin thiolesterase activity [IDA]
- ubiquitin-specific protease activity [IDA]
- ATPase binding [ISO]
- Lys48-specific deubiquitinase activity [ISO]
- Lys63-specific deubiquitinase activity [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin thiolesterase activity [IDA]
- ubiquitin-specific protease activity [IDA]
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR).
We describe a high-throughput in-cell nuclear magnetic resonance (NMR)-based method for mapping the structural changes that accompany protein-protein interactions (STINT-NMR). The method entails sequentially expressing two (or more) proteins within a single bacterial cell in a time-controlled manner and monitoring the protein interactions using in-cell NMR spectroscopy. The resulting spectra provide a complete titration of the interaction and define structural ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
- NMR
- This experiment was done in vivo in bacterial cells.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ATXN3 UBC | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 1108410 | |
UBC ATXN3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2297261 |
Curated By
- BioGRID