SCH9
Gene Ontology Biological Process
- age-dependent response to oxidative stress involved in chronological cell aging [IMP]
- positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase I promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase III promoter [IGI, IMP]
- protein phosphorylation [IMP]
- regulation of cell size [IMP]
- regulation of protein localization [IMP]
- regulation of response to osmotic stress [IMP]
- regulation of sphingolipid biosynthetic process [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
BCY1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Distinct regulation of Maf1 for lifespan extension by Protein kinase A and Sch9.
The Protein kinase A (PKA) and Sch9 regulates cell growth as well as lifespan in Saccharomyces cerevisiae. Maf1 is a RNA polymerase III (PolIII) inhibitor that tailors 5S rRNA and tRNA production in response to various environmental cues. Both PKA and Sch9 have been shown to phosphorylate Maf1 in vitro at similar amino acids, suggesting a redundancy in Maf1 regulation. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: chronological lifespan (APO:0000316)
Additional Notes
- deletion of Bcy1 abrogates the resistance to H202 seen in an sch9 mutant
- deletion of Bcy1 decreases the chronological lifespan increase seen in an sch9 mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SCH9 BCY1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 520104 | |
SCH9 BCY1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1113304 | |
SCH9 BCY1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 1113305 |
Curated By
- BioGRID