SNF1
Gene Ontology Biological Process
- cell adhesion [IMP]
- cellular response to nitrogen starvation [IDA]
- fungal-type cell wall assembly [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of translation [IGI, IMP]
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [IMP]
- positive regulation of gluconeogenesis [IMP]
- protein phosphorylation [IDA]
- pseudohyphal growth [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- replicative cell aging [IGI, IMP]
- single-species surface biofilm formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RPD3
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IMP]
- negative regulation of chromatin silencing at rDNA [IMP]
- negative regulation of chromatin silencing at silent mating-type cassette [IMP]
- negative regulation of chromatin silencing at telomere [IDA, IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- negative regulation of transcription during meiosis [IMP]
- negative regulation of transcription from RNA polymerase I promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, IPI]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- protein localization to nucleolar rDNA repeats [IMP]
- regulation of DNA-dependent DNA replication initiation [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IPI]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- replicative cell aging [IMP]
- transcription elongation from RNA polymerase II promoter [IGI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The yeast AMPK homolog SNF1 regulates acetyl coenzyme A homeostasis and histone acetylation.
Acetyl coenzyme A (acetyl-CoA) is a key metabolite at the crossroads of metabolism, signaling, chromatin structure, and transcription. Concentration of acetyl-CoA affects histone acetylation and links intermediary metabolism and transcriptional regulation. Here we show that SNF1, the budding yeast ortholog of the mammalian AMP-activated protein kinase (AMPK), plays a role in the regulation of acetyl-CoA homeostasis and global histone acetylation. ... [more]
Throughput
- Low Throughput
Ontology Terms
- heat sensitivity (APO:0000147)
- vegetative growth (APO:0000106)
Additional Notes
- Figure 5
- RPD3 deletion partially suppresses temperature-sensitivity of snf1 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPD3 SNF1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -7.64 | BioGRID | 2357067 | |
| SNF1 RPD3 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 256130 |
Curated By
- BioGRID