AZU1
Gene Ontology Biological Process
- cellular extravasation [NAS]
- defense response to Gram-negative bacterium [TAS]
- glial cell migration [IDA]
- induction of positive chemotaxis [NAS]
- inflammatory response [NAS]
- macrophage chemotaxis [NAS]
- microglial cell activation [IEP]
- monocyte activation [TAS]
- negative regulation of apoptotic process [NAS]
- positive regulation of MHC class II biosynthetic process [IEP]
- positive regulation of cell adhesion [IDA]
- positive regulation of fractalkine biosynthetic process [IDA]
- positive regulation of interleukin-1 beta biosynthetic process [IDA]
- positive regulation of phagocytosis [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [TAS]
- proteolysis [IBA]
- regulation of vascular permeability [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ZYG11B
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.966367851 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.966367851, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AZU1 ZYG11B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9861 | BioGRID | 2242965 | |
| AZU1 ZYG11B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9535 | BioGRID | 3055855 |
Curated By
- BioGRID