AZU1
Gene Ontology Biological Process
- cellular extravasation [NAS]
- defense response to Gram-negative bacterium [TAS]
- glial cell migration [IDA]
- induction of positive chemotaxis [NAS]
- inflammatory response [NAS]
- macrophage chemotaxis [NAS]
- microglial cell activation [IEP]
- monocyte activation [TAS]
- negative regulation of apoptotic process [NAS]
- positive regulation of MHC class II biosynthetic process [IEP]
- positive regulation of cell adhesion [IDA]
- positive regulation of fractalkine biosynthetic process [IDA]
- positive regulation of interleukin-1 beta biosynthetic process [IDA]
- positive regulation of phagocytosis [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [TAS]
- proteolysis [IBA]
- regulation of vascular permeability [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ZYG11B
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.953512295 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.953512295, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- BioPlex HCT HCT116 cells CompPASS score = 0.903347098, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AZU1 ZYG11B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9664 | BioGRID | 1176568 | |
| AZU1 ZYG11B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9861 | BioGRID | 2242965 |
Curated By
- BioGRID