AKR1C3
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- arachidonic acid metabolic process [TAS]
- cellular response to cadmium ion [IDA]
- cellular response to calcium ion [IDA]
- cellular response to corticosteroid stimulus [IDA]
- cellular response to jasmonic acid stimulus [IDA]
- cellular response to prostaglandin D stimulus [IDA]
- cellular response to prostaglandin stimulus [IDA]
- cellular response to reactive oxygen species [IDA]
- cellular response to starvation [IEP]
- cyclooxygenase pathway [TAS]
- daunorubicin metabolic process [IMP]
- doxorubicin metabolic process [IMP]
- farnesol catabolic process [IDA]
- keratinocyte differentiation [IEP]
- male gonad development [IEP]
- multicellular organismal macromolecule metabolic process [IEP]
- negative regulation of retinoic acid biosynthetic process [IDA]
- oxidation-reduction process [IDA, TAS]
- phototransduction, visible light [TAS]
- positive regulation of cell death [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- progesterone metabolic process [IDA]
- prostaglandin metabolic process [IEP, TAS]
- protein import into nucleus, translocation [IDA]
- regulation of retinoic acid receptor signaling pathway [IDA]
- regulation of testosterone biosynthetic process [IMP]
- renal absorption [NAS]
- response to nutrient [IEP]
- retinal metabolic process [IDA]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
- steroid metabolic process [IEP]
- testosterone biosynthetic process [IMP]
Gene Ontology Molecular Function- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase activity [IDA]
- delta4-3-oxosteroid 5beta-reductase activity [IDA]
- dihydrotestosterone 17-beta-dehydrogenase activity [IDA]
- geranylgeranyl reductase activity [IDA]
- ketoreductase activity [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- retinal dehydrogenase activity [IDA]
- retinol dehydrogenase activity [IDA]
- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase activity [IDA]
- delta4-3-oxosteroid 5beta-reductase activity [IDA]
- dihydrotestosterone 17-beta-dehydrogenase activity [IDA]
- geranylgeranyl reductase activity [IDA]
- ketoreductase activity [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- retinal dehydrogenase activity [IDA]
- retinol dehydrogenase activity [IDA]
Gene Ontology Cellular Component
AKR1C4
Gene Ontology Biological Process
- androgen metabolic process [TAS]
- bile acid and bile salt transport [TAS]
- bile acid biosynthetic process [TAS]
- bile acid metabolic process [TAS]
- cellular response to jasmonic acid stimulus [IDA]
- daunorubicin metabolic process [IMP]
- doxorubicin metabolic process [IMP]
- phototransduction, visible light [TAS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
- steroid metabolic process [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 1.0 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 1.0, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AKR1C3 AKR1C4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2216320 | |
| AKR1C4 AKR1C3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3157633 | |
| AKR1C3 AKR1C4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3136241 |
Curated By
- BioGRID