WNT3A
Gene Ontology Biological Process
- COP9 signalosome assembly [ISS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [IDA]
- cell proliferation in forebrain [ISS]
- cellular response to retinoic acid [ISS]
- negative regulation of heart induction by canonical Wnt signaling pathway [IDA]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron projection development [ISS]
- neuron differentiation [IBA, ISS]
- palate development [IMP]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of dermatome development [IDA]
- positive regulation of mesodermal cell fate specification [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT3
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [IMP]
- canonical Wnt signaling pathway involved in osteoblast differentiation [IMP]
- cell fate commitment [IBA]
- cell morphogenesis [IMP]
- cellular response to retinoic acid [ISS]
- limb bud formation [IMP]
- mammary gland epithelium development [IEP]
- neuron differentiation [IBA, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.999999999 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999999999, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
WNT3A WNT3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2216551 | |
WNT3 WNT3A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3282778 | |
WNT3 WNT3A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3124695 |
Curated By
- BioGRID