WNT4
Gene Ontology Biological Process
- adrenal gland development [IEP]
- androgen biosynthetic process [IDA]
- canonical Wnt signaling pathway [IDA]
- cell fate commitment [IBA]
- cellular response to transforming growth factor beta stimulus [IEP]
- epithelial to mesenchymal transition [IEP]
- establishment of protein localization to plasma membrane [IDA]
- female gonad development [ISS]
- female sex determination [IMP]
- kidney development [IEP]
- liver development [IEP]
- male gonad development [IEP, IMP]
- mammary gland epithelium development [IEP]
- metanephric mesenchymal cell differentiation [NAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of male gonad development [IMP]
- negative regulation of steroid biosynthetic process [IDA]
- negative regulation of testicular blood vessel morphogenesis [IMP]
- negative regulation of testosterone biosynthetic process [IMP]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- neuron differentiation [IBA]
- non-canonical Wnt signaling pathway via MAPK cascade [IDA]
- paramesonephric duct development [IMP]
- positive regulation of aldosterone biosynthetic process [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cortisol biosynthetic process [IDA]
- positive regulation of dermatome development [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- protein palmitoylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA5
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- ER-associated ubiquitin-dependent protein catabolic process [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- maintenance of protein localization in endoplasmic reticulum [IMP]
- negative regulation of apoptotic process [IMP, TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cell migration [IMP]
- regulation of protein folding in endoplasmic reticulum [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- endoplasmic reticulum [IDA, IMP, TAS]
- endoplasmic reticulum chaperone complex [IDA]
- endoplasmic reticulum lumen [TAS]
- endoplasmic reticulum membrane [TAS]
- endoplasmic reticulum-Golgi intermediate compartment [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- membrane [IDA]
- midbody [IDA]
- nucleus [IDA, IMP]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.809856723 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.809856723, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
WNT4 HSPA5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7537 | BioGRID | 2272506 | |
WNT4 HSPA5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.6084 | BioGRID | 3245861 | |
WNT4 HSPA5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7747 | BioGRID | 3144231 |
Curated By
- BioGRID