RGCC
Gene Ontology Biological Process
- cellular response to hypoxia [IMP]
- complement activation [IMP]
- fibroblast activation [ISS]
- mitotic cell cycle arrest [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion mediated by cadherin [IDA]
- negative regulation of cytokine secretion [IMP]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of exit from mitosis [IDA]
- negative regulation of fibroblast growth factor production [IDA]
- negative regulation of mitotic cell cycle phase transition [IDA]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of cytokine secretion [IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA, IMP]
- positive regulation of extracellular matrix constituent secretion [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of stress fiber assembly [IDA]
Gene Ontology Molecular Function
TLN1
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-cell junction assembly [TAS]
- cellular component movement [NAS]
- cellular protein metabolic process [TAS]
- cytoskeletal anchoring at plasma membrane [NAS]
- endoplasmic reticulum unfolded protein response [TAS]
- muscle contraction [TAS]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.9994741 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.9994741, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9926 | BioGRID | 2239747 | |
| RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.947 | BioGRID | 3253685 | |
| RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9937 | BioGRID | 3115216 |
Curated By
- BioGRID