BAIT
SOX4
EVI16
SRY (sex determining region Y)-box 4
GO Process (41)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP]
- T cell differentiation [ISS]
- ascending aorta morphogenesis [ISS]
- atrial septum primum morphogenesis [ISS]
- canonical Wnt signaling pathway [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac ventricle formation [ISS]
- cellular response to glucose stimulus [ISS]
- glial cell development [ISS]
- glial cell proliferation [ISS]
- glucose homeostasis [ISS]
- heart development [ISS]
- kidney morphogenesis [ISS]
- limb bud formation [ISS]
- mitral valve morphogenesis [ISS]
- negative regulation of cell death [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of protein ubiquitination [IMP]
- neural tube formation [ISS]
- neuroepithelial cell differentiation [ISS]
- noradrenergic neuron differentiation [ISS]
- positive regulation of N-terminal peptidyl-lysine acetylation [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of insulin secretion [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of translation [IMP]
- pro-B cell differentiation [ISS]
- protein stabilization [IMP]
- regulation of protein stability [IMP]
- regulation of transcription, DNA-templated [IDA]
- skeletal system development [ISS]
- spinal cord development [ISS]
- spinal cord motor neuron differentiation [ISS]
- sympathetic nervous system development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
IGF1
IGF-I, IGF1A, IGFI
insulin-like growth factor 1 (somatomedin C)
GO Process (50)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- DNA replication [TAS]
- Ras protein signal transduction [TAS]
- blood coagulation [TAS]
- bone mineralization involved in bone maturation [IDA]
- cell activation [IDA]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- glycolate metabolic process [TAS]
- muscle hypertrophy [IMP]
- muscle organ development [TAS]
- myoblast differentiation [IDA]
- myoblast proliferation [IDA]
- myotube cell development [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of oocyte development [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISS]
- negative regulation of smooth muscle cell apoptotic process [IDA]
- phosphatidylinositol-mediated signaling [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of DNA binding [IDA]
- positive regulation of DNA replication [IDA, ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of activated T cell proliferation [IDA]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cardiac muscle hypertrophy [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IDA]
- positive regulation of insulin-like growth factor receptor signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein import into nucleus, translocation [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- proteoglycan biosynthetic process [IDA]
- regulation of gene expression [IMP]
- regulation of multicellular organism growth [IEP]
- signal transduction [TAS]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Transcriptional regulatory network of SOX4 during myoblast differentiation.
The construction of transcriptional regulatory networks of transcription factors (TFs) has become more important and attractive to understand the alterations of binding protein-dependent transcriptional activity that governs the changes in spatiotemporal expression of TF target genes required in various cellular processes. Therefore, identification of new inner modules including target genes and protein interactions involved in unveiled TF-based transcription networks is ... [more]
Biochem. Biophys. Res. Commun. Jul. 10, 2015; 462(4);365-70 [Pubmed: 25969425]
Throughput
- Low Throughput
Curated By
- BioGRID