SAE2
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA, IMP]
- DNA double-strand break processing [IGI]
- DNA double-strand break processing involved in repair via synthesis-dependent strand annealing [IMP]
- gene conversion at mating-type locus, DNA double-strand break processing [IMP]
- meiotic DNA double-strand break formation [IGI]
- meiotic DNA double-strand break processing [IGI, IMP]
- telomere maintenance [IMP]
- telomeric 3' overhang formation [IMP]
Gene Ontology Molecular Function
SAE2
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA, IMP]
- DNA double-strand break processing [IGI]
- DNA double-strand break processing involved in repair via synthesis-dependent strand annealing [IMP]
- gene conversion at mating-type locus, DNA double-strand break processing [IMP]
- meiotic DNA double-strand break formation [IGI]
- meiotic DNA double-strand break processing [IGI, IMP]
- telomere maintenance [IMP]
- telomeric 3' overhang formation [IMP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.
In the DNA damage response, many repair and signaling molecules mobilize rapidly at the sites of DNA double-strand breaks. This network of immediate responses is regulated at the level of posttranslational modifications that control the activation of DNA processing enzymes, protein kinases, and scaffold proteins to coordinate DNA repair and checkpoint signaling. Here we investigated the DNA damage-induced oligomeric transitions ... [more]
Throughput
- Low Throughput
Additional Notes
- oligomer
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SAE2 SAE2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
SAE2 SAE2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 2511679 | |
SAE2 SAE2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 268410 | |
SAE2 SAE2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID