BAIT
USP7
HAUSP, TEF1
ubiquitin specific peptidase 7 (herpes virus-associated)
GO Process (8)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- histone deubiquitination [IBA]
- maintenance of DNA methylation [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of sequence-specific DNA binding transcription factor activity [IDA]
- transcription-coupled nucleotide-excision repair [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
DYNC1H1
DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22
dynein, cytoplasmic 1, heavy chain 1
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.
The de-ubiquitinase HAUSP has been reported to exhibit various biological roles implicated in the development of cancer and other pathologies. The dual nature of HAUSP (i.e., oncogenic and tumor suppressive) makes the protein even more versatile. The major aims of this study were to reveal the effect of HAUSP over-expression on the overall proteome and to identify bona fide substrates ... [more]
Cell Oncol (Dordr) Aug. 01, 2015; 38(4);265-77 [Pubmed: 25925205]
Throughput
- High Throughput
Curated By
- BioGRID