BAIT
PIK3R5
F730038I15Rik, FOAP-2, P101-PI3K, p101
phosphoinositide-3-kinase, regulatory subunit 5
GO Process (9)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- blood coagulation [TAS]
- phosphatidylinositol 3-kinase signaling [ISS]
- phosphatidylinositol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of protein kinase B signaling [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
GNB1
RP1-283E3.7
guanine nucleotide binding protein (G protein), beta polypeptide 1
GO Process (16)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [TAS]
- GTP catabolic process [IDA, TAS]
- Ras protein signal transduction [TAS]
- adenylate cyclase-activating dopamine receptor signaling pathway [ISS]
- blood coagulation [TAS]
- cellular response to catecholamine stimulus [ISS]
- cellular response to glucagon stimulus [TAS]
- cellular response to prostaglandin E stimulus [ISS]
- energy reserve metabolic process [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- regulation of rhodopsin mediated signaling pathway [TAS]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.
Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P2 to PtdIns-3,4,5-P3. This, in turn, recruits and activates cytosolic effectors with PtdIns-3,4,5-P3-binding pleckstrin homology (PH) domains, thereby controlling important cellular functions such as proliferation, survival, or chemotaxis. The class IB p110 gamma/p101 PI3K gamma is activated by G beta gamma on stimulation of G protein-coupled receptors. It is ... [more]
J. Cell Biol. Jan. 06, 2003; 160(1);89-99 [Pubmed: 12507995]
Throughput
- Low Throughput
Additional Notes
- coexpression of heterodimeric PI3Kgamma together with Gbetagamma produced a rounded morphology and detachment of the cells
- genetic complex
Curated By
- BioGRID