BAIT
PIK3CG
PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
GO Process (25)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- T cell activation [TAS]
- T cell chemotaxis [TAS]
- T cell proliferation [TAS]
- adaptive immune response [TAS]
- blood coagulation [TAS]
- cytokine production [TAS]
- dendritic cell chemotaxis [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- mast cell degranulation [TAS]
- natural killer cell chemotaxis [TAS]
- negative regulation of cardiac muscle contraction [TAS]
- neutrophil chemotaxis [TAS]
- neutrophil extravasation [TAS]
- phosphatidylinositol 3-kinase signaling [IDA, TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- platelet aggregation [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of protein kinase B signaling [IDA]
- regulation of cell adhesion mediated by integrin [TAS]
- respiratory burst involved in defense response [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNG2
guanine nucleotide binding protein (G protein), gamma 2
GO Process (9)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- adenylate cyclase-activating dopamine receptor signaling pathway [ISS]
- blood coagulation [TAS]
- cellular response to catecholamine stimulus [ISS]
- cellular response to glucagon stimulus [TAS]
- cellular response to prostaglandin E stimulus [ISS]
- energy reserve metabolic process [TAS]
- platelet activation [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.
Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P2 to PtdIns-3,4,5-P3. This, in turn, recruits and activates cytosolic effectors with PtdIns-3,4,5-P3-binding pleckstrin homology (PH) domains, thereby controlling important cellular functions such as proliferation, survival, or chemotaxis. The class IB p110 gamma/p101 PI3K gamma is activated by G beta gamma on stimulation of G protein-coupled receptors. It is ... [more]
J. Cell Biol. Jan. 06, 2003; 160(1);89-99 [Pubmed: 12507995]
Throughput
- Low Throughput
Additional Notes
- coexpression of heterodimeric PI3Kgamma together with Gbetagamma produced a rounded morphology and detachment of the cells
- genetic complex
Curated By
- BioGRID